Brd4 Is Involved in Multiple Processes of the Bovine Papillomavirus Type 1 Life Cycle-Reference-Cited by-同舟云学术

Brd4 Is Involved in Multiple Processes of the Bovine Papillomavirus Type 1 Life Cycle

Published:2006-04 Issue:7 Volume:80 Page:3660-3665
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ilves Ivar¹,Mäemets Kristina²,Silla Toomas²,Janikson Kadri²,Ustav Mart¹²

Affiliation:

1. Institute of Technology

2. Department of Microbiology and Virology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia

Abstract

ABSTRACT Brd4 protein has been proposed to act as a cellular receptor for the bovine papillomavirus type 1 (BPV1) E2 protein in the E2-mediated chromosome attachment and mitotic segregation of viral genomes. Here, we provide data that show the involvement of Brd4 in multiple early functions of the BPV1 life cycle, suggest a Brd4-dependent mechanism for E2-dependent transcription activation, and indicate the role of Brd4 in papillomavirus and polyomavirus replication as well as cell-specific utilization of Brd4-linked features in BPV1 DNA replication. Our data also show the potential therapeutic value of the disruption of the E2-Brd4 interaction for the development of antiviral drugs.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.80.7.3660-3665.2006

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