Author:
Ikawa S,Fukui M,Ueyama Y,Tamaoki N,Yamamoto T,Toyoshima K
Abstract
Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Cited by
133 articles.
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