The Foot-and-Mouth Disease Virus cis -Acting Replication Element ( cre ) Can Be Complemented in trans within Infected Cells-Reference-Cited by-同舟云学术

The Foot-and-Mouth Disease Virus cis -Acting Replication Element ( cre ) Can Be Complemented in trans within Infected Cells

Published:2003-02 Issue:3 Volume:77 Page:2243-2246
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tiley Laurence¹,King Andrew M. Q.¹,Belsham Graham J.¹

Affiliation:

1. Institute for Animal Health, Pirbright, Woking, Surrey GU24 ONF, United Kingdom

Abstract

ABSTRACT A temperature-sensitive ( ts ) mutation was identified within the 5′-untranslated region of foot-and-mouth disease virus (FMDV) RNA. The mutation destabilizes a stem-loop structure recently identified as a cis -acting replication element ( cre ). Genetic analyses indicated that the ts defect in virus replication could be complemented. Thus, the FMDV cre can function in trans . It is suggested that the cre be renamed a 3B-uridylylation site ( bus ).

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.3.2243-2246.2003

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