Rapid Elimination of Broadly Neutralizing Antibodies Correlates with Treatment Failure in the Acute Phase of Simian-Human Immunodeficiency Virus Infection-Reference-Cited by-同舟云学术

Rapid Elimination of Broadly Neutralizing Antibodies Correlates with Treatment Failure in the Acute Phase of Simian-Human Immunodeficiency Virus Infection

Published:2019-10-15 Issue:20 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wu Yanling¹,Xue Jing²,Wang Chunyu¹,Li Wei³,Wang Lili¹,Chen Weizao³,Prabakaran Ponraj⁴,Kong Desheng⁵,Jin Yujia¹,Hu Dan¹,Wang Yulu¹,Lei Cheng¹,Yu Diao¹⁶,Tu Chao⁶,Bardhi Ariola⁷⁸,Sidorov Igor⁹,Ma Liying⁵,Goldstein Harris⁷⁸,Qin Chuan²,Lu Lu¹,Jiang Shibo¹,Dimitrov Dimiter S.³,Ying Tianlei¹

Affiliation:

1. MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

2. Key Laboratory of Human Disease Comparative Medicine of Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Re-emerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College, Beijing, China

3. Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA

4. Intrexon Corporation, Germantown, Maryland, USA

5. State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention, Beijing, China

6. Biomissile Corporation, Shanghai, China

7. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

8. Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA

9. Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

Abstract

Currently, there is no bnAb-based monotherapy that has been reported to clear the virus in the acute SHIV infection period. Since early HIV treatment is considered critical to restricting the establishment of viral reservoirs, investigation into the mechanism for treatment failure in acutely infected macaques would be important for the therapeutic use of bnAbs and eventually towards the functional cure of HIV/AIDS. Here we report the comparative study of the therapeutic efficacy of a bnAb in acutely and chronically SHIV-infected macaques. This study revealed the correlation between the fast clearance of infused bnAbs and treatment failure during the acute period of infection.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01077-19

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