Changes in the Molecular and Functional Phenotype of Bovine Monocytes during Theileria parva Infection-Reference-Cited by-同舟云学术

Changes in the Molecular and Functional Phenotype of Bovine Monocytes during Theileria parva Infection

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bastos Reginaldo G.¹,Sears Kelly¹²,Dinkel Kelcey D.¹,Knowles Donald P.¹,Fry Lindsay M.¹³

Affiliation:

1. Department of Veterinary Microbiology & Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA

2. Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA

3. Animal Disease Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, Washington, USA

Abstract

Theileria parva is the causative agent of East Coast fever (ECF), a tick-borne disease that kills over a million cattle each year in sub-Saharan Africa. Immune protection against T. parva involves a CD8 + cytotoxic T cell response to parasite-infected cells. However, there is currently a paucity of knowledge regarding the role played by innate immune cells in ECF pathogenesis and T. parva control.

Funder

United States Agency for International Development

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00703-19

Reference52 articles.

1. The biology of Theileria parva and control of East Coast fever – Current status and future trends

2. Chemical control of ticks on cattle and the resistance of these parasites to acaricides