<i>In Vitro</i> Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus-Reference-Cited by-同舟云学术

In Vitro Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus

Published:2022-05-17 Issue:5 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Schulthess Bettina¹²^ORCID,Akdoğan Kittana Fatma Nur¹^ORCID,Hömke Rico¹²,Sander Peter¹²^ORCID

Affiliation:

1. Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

2. National Reference Center for Mycobacteria, Zurich, Switzerland

Abstract

Bedaquiline and clofazimine are increasingly used to treat infections with Mycobacterium abscessus . We determined distributions of MICs by broth microdilution for bedaquiline and clofazimine for 61 M. abscessus clinical isolates using different media and incubation times. We show that incubation time and growth media critically influence the MIC. Our data will aid in defining future clinical breakpoints for in vitro susceptibility testing for bedaquiline and clofazimine in M. abscessus .

Funder

Swiss National Science Foundation

Federal Office of Public Health

TUBITAK Turkey

Schweizerische Gesellschaft fuer Cystische Firbrose

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02346-21

Reference41 articles.