Overcoming Hurdles to Development of a Vaccine against Pneumocystis jirovecii-Reference-Cited by-同舟云学术

Overcoming Hurdles to Development of a Vaccine against Pneumocystis jirovecii

Published:2017-04 Issue:4 Volume:85 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Garvy Beth A.¹

Affiliation:

1. Department of Microbiology, Immunology and Molecular Genetics and Division of Infectious Diseases, University of Kentucky College of Medicine, Lexington, Kentucky, USA

Abstract

ABSTRACT Development of Pneumocystis pneumonia (PCP) is a common problem among immunosuppressed individuals. There are windows of opportunity in which vaccination would be beneficial, but to date, no vaccines have made it to clinical trials. Significant hurdles to vaccine development include host range specificity, making it difficult to translate from animal models to humans. Discovery of cross-reactive epitopes is critical to moving vaccine candidates from preclinical animal studies to clinical trials.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00035-17

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