A Phenome-Wide Association Study Uncovers a Pathological Role of Coagulation Factor X during Acinetobacter baumannii Infection

Author:

Choby Jacob E.12ORCID,Monteith Andrew J.1,Himmel Lauren E.1,Margaritis Paris34,Shirey-Rice Jana K.5,Pruijssers Andrea5,Jerome Rebecca N.5,Pulley Jill5,Skaar Eric P.16

Affiliation:

1. Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Graduate Program in Microbiology & Immunology, Vanderbilt University, Nashville, Tennessee, USA

3. Department of Pediatrics and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

4. Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, USA

5. Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA

6. Vanderbilt Institute for Infection, Immunology & Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Coagulation and inflammation are interconnected, suggesting that coagulation plays a key role in the inflammatory response to pathogens. A phenome-wide association study (PheWAS) was used to identify clinical phenotypes of patients with a polymorphism in coagulation factor X.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Advancing Translational Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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