In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth

Author:

Karlowsky J A1,Zhanel G G1,Davidson R J1,Zieroth S R1,Hoban D J1

Affiliation:

1. Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.

Abstract

Multiple exposures with cefotaxime in either Mueller-Hinton broth or cerebrospinal fluid had no effect on killing or the duration of postantibiotic effect (PAE) in Escherichia coli strains tested. However, upon multiple exposures in Mueller-Hinton broth, ciprofloxacin and gentamicin PAEs significantly decreased with a concomitant reduction in bacterial killing. A reduction in bacterial killing following multiple ciprofloxacin and gentamicin exposures was also seen with cerebrospinal fluid; however, the PAE was maintained.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference14 articles.

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2. Craig W. A. and S. Gudmundsson. 1991. Postantibiotic effect p. 403-431. In V. Lorian (ed.) Antibiotics in laboratory medicine 3rd ed. The Williams & Wilkins Co. Baltimore.

3. Adaptive resistance to aminoglycoside antibiotics from first exposure down-regulation;Daikos G. L.;J. Infect. Dis.,1990

4. Human serum enhances the postantibiotic effect of fluoroquinolones against Staphylococcus aureus;Davidson R. J.;Antimicrob. Agents Chemother.,1991

5. Ionic binding, adaptive resistance and post-antibiotic effect of netilmicin and ciprofloxacin;Gould I. M.;J. Antimicrob. Chemother.,1991

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