In vitro susceptibility of Streptococcus mutans to chlorhexidine and six other antimicrobial agents

Author:

Järvinen H1,Tenovuo J1,Huovinen P1

Affiliation:

1. Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland.

Abstract

The susceptibility of Streptococcus mutans to chlorhexidine and to six commonly used, systemic antibacterial agents (amoxicillin, cefuroxime, penicillin, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin) was studied for 424 clinical isolates from 116 children and students. The MIC of chlorhexidine for all isolates was < or = 1 micrograms/ml. No resistance to the other antimicrobial agents was detected. Although widely exposed to various antimicrobial agents, S. mutans has remained susceptible to common antimicrobial agents, most importantly to chlorhexidine.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference22 articles.

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2. Prevention of excess neonatal morbidity associated with group B streptococci by vaginal chlorhexidine disinfection during labour;Burman L. G.;Lancet,1992

3. Oral changes associated with six months' exposure to chlorhexidine;Dever J. G.;J. Dent. Res.,1982

4. Comparative efficacy of alternative hand-washing agents in reducing nosocomial infections in intensive care units;Doebbeling B. N.;N. Engl. J. Med.,1992

5. Susceptibility of various microorganisms to chlorhexidine;Emilson C. G.;Scand. J. Dent. Res.,1977

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