Chlamydiae Modulate Gamma Interferon, Interleukin-1β, and Tumor Necrosis Factor Alpha Receptor Expression in HeLa Cells

Author:

Shirey Kari Ann1,Carlin Joseph M.1

Affiliation:

1. Department of Microbiology, Miami University, Oxford, Ohio

Abstract

ABSTRACT Chlamydia psittaci was found to modulate receptor expression for the cytokine receptors that are involved in the synergistic induction of indoleamine dioxygenase in epithelial cells. Increases in receptor expression were seen even with inactivated Chlamydia , suggesting that chlamydial antigens and not products of infection are important for up-regulating cytokine receptor expression.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference30 articles.

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3. Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells

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5. Carlin, J. M., E. C. Borden, and G. I. Byrne. 1989. Interferon-induced indoleamine 2,3-dioxygenase activity inhibits Chlamydia psittaci replication in human macrophages. J. Interferon Res.9:329-337.

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