Association of Composite IS26-sul3Elements with Highly Transmissible IncI1 Plasmids in Extended-Spectrum-β-Lactamase-Producing Escherichia coli Clones from Humans

Author:

Curiao Tânia,Cantón Rafael,Garcillán-Barcia M. Pilar,de la Cruz Fernando,Baquero Fernando,Coque Teresa M.

Abstract

ABSTRACTThe association of an IS440-sul3platform with Tn21class 1 integrons carried by IncI1 plasmids encoding extended-spectrum β-lactamases (ESBLs; mainly SHV-12 and CTX-M-14) among worldwideEscherichia coliclones of phylogroups A (ST10, ST23, and ST46), B1 (ST155, ST351, and ST359), and D/B2 (ST131) is reported. Anin silicocomparative analysis ofsul3elements available in the GenBank database shows the evolution ofsul3platforms by hosting different transposable elements facilitating the potential genesis of IS26composite transposons and further insertion element-mediated promoted arrangements.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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