Mutant Prevention Concentrations of Fluoroquinolones for Enterobacteriaceae Expressing the Plasmid-Carried Quinolone Resistance Determinant qnrA1-Reference-Cited by-同舟云学术

Mutant Prevention Concentrations of Fluoroquinolones for Enterobacteriaceae Expressing the Plasmid-Carried Quinolone Resistance Determinant qnrA1

Published:2007-06 Issue:6 Volume:51 Page:2236-2239
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rodríguez-Martínez J. M.¹,Velasco C.¹,García I.¹,Cano M. E.²,Martínez-Martínez L.²,Pascual A.¹³

Affiliation:

1. Department of Microbiology, University of Seville, Seville

2. Service of Microbiology, University Hospital Marqués de Valdecilla, Santander, Spain

3. Service of Microbiology, University Hospital Virgen Macarena, Seville

Abstract

ABSTRACT The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1 , mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01444-06

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