In Vitro Activity of 2,4-Diamino-6-[2-(Phosphonomethoxy)Ethoxy]-Pyrimidine against Multidrug-Resistant Hepatitis B Virus Mutants-Reference-Cited by-同舟云学术

In Vitro Activity of 2,4-Diamino-6-[2-(Phosphonomethoxy)Ethoxy]-Pyrimidine against Multidrug-Resistant Hepatitis B Virus Mutants

Published:2007-06 Issue:6 Volume:51 Page:2240-2243
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Brunelle M. N.¹²³,Lucifora J.¹²³,Neyts J.⁴,Villet S.¹²³,Holy A.⁵,Trepo C.¹²³⁶,Zoulim F.¹²³⁶

Affiliation:

1. INSERM, U871, 151 Cours Albert Thomas, 69003 Lyon, France

2. Université Lyon 1, 69008 Lyon, France

3. IFR62 Lyon Est, Faculté de Médecine Laennec, 69008 Lyon, France

4. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium

5. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

6. Hospices Civils de Lyon, Hôtel Dieu Hospital, 69002 Lyon, France

Abstract

ABSTRACT The susceptibilities of drug-resistant hepatitis B virus (HBV) mutants to lamivudine, adefovir, tenofovir, entecavir, and 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine (PMEO-DAPym), a novel acyclic pyrimidine analogue, were assessed in vitro. Most drug-resistant mutants, including multidrug-resistant strains, remained sensitive to tenofovir and PMEO-DAPym. Therefore, the latter molecule deserves further evaluation for the treatment of HBV infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01440-06

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