Moloney Murine Leukemia Virus p12 Is Required for Histone Loading onto Retroviral DNAs-Reference-Cited by-同舟云学术

Moloney Murine Leukemia Virus p12 Is Required for Histone Loading onto Retroviral DNAs

Published:2021-07-12 Issue:15 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wang Gary Z.¹,Goff Stephen P.²³⁴^ORCID

Affiliation:

1. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA

2. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA

3. Department of Microbiology and Immunology, Columbia University, New York, New York, USA

4. Howard Hughes Medical Institute, Chevy Chase, Maryland, USA

Abstract

Incoming retroviral DNAs are rapidly loaded with nucleosomal histones upon entry into the nucleus and before integration into the host genome. The entry of murine leukemia virus DNA into the nucleus occurs only upon dissolution of the nuclear membrane in mitosis, and retention in the nucleus requires the action of a viral protein, p12, which tethers the DNA to host chromatin.

Funder

HHS | NIH | National Cancer Institute

Howard Hughes Medical Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00495-21

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