Affiliation:
1. Johnson & Johnson Pharmaceutical Research & Development, LLC, Raritan, New Jersey
Abstract
ABSTRACT
The activities of ceftobiprole and other β-lactams were examined with 30
Streptococcus pneumoniae
isolates containing multiple
pbp1a
,
pbp2b
, and
pbp2x
mutations. The highest ceftobiprole MIC was 1 μg/ml, while the comparator MICs were 16 to 64 μg/ml. Fifty percent inhibitory concentrations for penicillin-binding protein 2x were 0.5 μg/ml (ceftobiprole) and 4 μg/ml (ceftriaxone) in a penicillin- and ceftriaxone-resistant isolate.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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