Secreted Aspartyl Proteinases and Interactions of Candida albicans with Human Endothelial Cells-Reference-Cited by-同舟云学术

Secreted Aspartyl Proteinases and Interactions of Candida albicans with Human Endothelial Cells

Published:1998-06 Issue:6 Volume:66 Page:3003-3005
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ibrahim Ashraf S.¹,Filler Scott G.¹²,Sanglard Dominique³,Edwards John E.¹²,Hube Bernhard⁴

Affiliation:

1. Division of Infectious Diseases, St. John’s Cardiovascular Research Center, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 905091;

2. UCLA School of Medicine, Los Angeles, California 900242;

3. Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland3; and

4. Institut für Allgemeine Botanik, AMP III, Universität Hamburg, D-22609 Hamburg, Germany4

Abstract

ABSTRACT The endothelial cell interactions of homozygous null mutants of Candida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicans adherence to endothelial cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.6.3003-3005.1998

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