A Translation-Aborting Small Open Reading Frame in the Intergenic Region Promotes Translation of a Mg 2+ Transporter in Salmonella Typhimurium

Author:

Choi Eunna1,Han Yoontak1,Park Shinae2,Koo Hyojeong2,Lee Jung-Shin2,Lee Eun-Jin1ORCID

Affiliation:

1. Department of Life Sciences, School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea

2. Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea

Abstract

Translation initiation regions in mRNAs that include the ribosome-binding site (RBS) and the start codon are often sequestered within a secondary structure. Therefore, to initiate protein synthesis, the mRNA secondary structure must be unfolded to allow the RBS to be accessible to the ribosome.

Funder

National Research Foundation of Korea

Korea University

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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