Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins-Reference-Cited by-同舟云学术

Genetic Evidence for SecY Translocon-Mediated Import of Two Contact-Dependent Growth Inhibition (CDI) Toxins

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Jones Allison M.¹²,Virtanen Petra²,Hammarlöf Disa²,Allen William J.³^ORCID,Collinson Ian³^ORCID,Hayes Christopher S.¹⁴,Low David A.¹⁴,Koskiniemi Sanna²^ORCID

Affiliation:

1. Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA

2. Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden

3. School of Biochemistry, University of Bristol, Bristol, United Kingdom

4. Biomolecular Science and Engineering Program, University of California, Santa Barbara, Santa Barbara, California, USA

Abstract

Many bacterial species interact via direct cell-to-cell contact using CDI systems, which provide a mechanism to inject toxins that inhibit bacterial growth into one another. Here, we find that two CDI toxins, one that depolarizes membranes and another that degrades RNA, exploit the universally conserved SecY translocon machinery used to export proteins for target cell entry.

Funder

HHS | National Institutes of Health

UKRI | Biotechnology and Biological Sciences Research Council

Wellcome

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03367-20

Reference59 articles.

1. Channel crossing: how are proteins shipped across the bacterial plasma membrane?