Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection-Reference-Cited by-同舟云学术

Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Peñaloza Hernán F.¹^ORCID,Olonisakin Tolani F.¹,Bain William G.¹,Qu Yanyan¹,van der Geest Rick¹,Zupetic Jill¹,Hulver Mei¹,Xiong Zeyu¹,Newstead Michael W.²,Zou Chunbin¹,Alder Jonathan K.¹,Ybe Joel A.³,Standiford Theodore J.²,Lee Janet S.¹^ORCID

Affiliation:

1. Acute Lung Injury Center of Excellence, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA

3. Department of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, Indiana, USA

Abstract

Pseudomonas aeruginosa pulmonary infection can lead to exaggerated neutrophilic inflammation and tissue destruction, yet host factors that regulate the neutrophilic response is not fully known. IL-36γ is a proinflammatory cytokine that dramatically increases in bioactivity following N-terminal processing by proteases.

Funder

HHS | National Institutes of Health

Pitt | Vascular Medicine Institute, University of Pittsburgh

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03336-20

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