A Novel Trichomonas vaginalis Surface Protein Modulates Parasite Attachment via Protein:Host Cell Proteoglycan Interaction

Author:

Molgora Brenda M.12,Rai Anand Kumar2,Sweredoski Michael J.3,Moradian Annie3,Hess Sonja3,Johnson Patricia J.12

Affiliation:

1. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA

2. Department of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA

3. Proteome Exploration Laboratory, Division of Biology and Biological Engineering, Beckman Institute, California Institute of Technology, Pasadena, California, USA

Abstract

The ability of the sexually transmitted parasite Trichomonas vaginalis to adhere to its human host is critical for establishing and maintaining an infection. Yet how parasites adhere to host cells is poorly understood.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | Office of Extramural Research, National Institutes of Health

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference76 articles.

1. WHO. 2012. Global incidence and prevalence of selected curable sexually transmitted infections: 2008. WHO, Geneva, Switzerland.

2. WHO. 2018. Report on global sexually transmitted infection surveillance, 2018. WHO, Geneva, Switzerland.

3. CDC. 2019. STD surveillance 2018. WHO, Geneva, Switzerland.

4. CDC. 2013. Incidence, prevalence, and cost of sexually transmitted infections in the United States. WHO, Geneva, Switzerland.

5. Clinical and Microbiological Aspects of Trichomonas vaginalis

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