Plasticity of the Influenza Virus H5 HA Protein-Reference-Cited by-同舟云学术

Plasticity of the Influenza Virus H5 HA Protein

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kong Huihui¹,Burke David F.²,da Silva Lopes Tiago Jose¹,Takada Kosuke³,Imai Masaki³,Zhong Gongxun¹,Hatta Masato¹,Fan Shufang¹,Chiba Shiho¹,Smith Derek²,Neumann Gabriele¹,Kawaoka Yoshihiro¹³⁴^ORCID

Affiliation:

1. Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA

2. Department of Zoology, University of Cambridge, Cambridge, United Kingdom

3. Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

4. International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Abstract

The HA protein of influenza A viruses is the major viral antigen. In this study, we simultaneously introduced mutations at 17 amino acid positions of an H5 HA expected to affect antigenicity. Viruses with ≥13 amino acid changes in HA were viable, and some had altered antigenic properties. H5 HA can therefore accommodate many mutations in regions that affect antigenicity. The substantial plasticity of H5 HA may facilitate the emergence of novel antigenic variants.

Funder

HHS | National Institutes of Health

Japan Agency for Medical Research and Development

HHS | Biomedical Advanced Research and Development Authority

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03324-20

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