TIR-Domain-Containing Adapter-Inducing Interferon-β (TRIF)-Dependent Antiviral Responses Protect Mice against Ross River Virus Disease

Author:

Liu Xiang1234ORCID,Taylor Adam1234ORCID,Poo Yee Suan12,Ng Wern Hann234ORCID,Herrero Lara J.1ORCID,Tang Patrick Chun Hean234,Zaid Ali1234ORCID,Mahalingam Suresh1234ORCID

Affiliation:

1. Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia

2. Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia

3. Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, Queensland, Australia

4. School of Medical Sciences, Griffith University, Gold Coast, Queensland, Australia

Abstract

RRV has been prevalent in the South Pacific region for decades and causes substantial economic and social costs. Though RRV is geographically restricted, a number of other alphaviruses have spread globally due to expansion of the mosquito vectors and increased international travel.

Funder

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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