A Novel Enterococcus faecalis Heme Transport Regulator (FhtR) Senses Host Heme To Control Its Intracellular Homeostasis-Reference-Cited by-同舟云学术

A Novel Enterococcus faecalis Heme Transport Regulator (FhtR) Senses Host Heme To Control Its Intracellular Homeostasis

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Saillant Vincent¹,Lipuma Damien¹,Ostyn Emeline¹,Joubert Laetitia¹,Boussac Alain²,Guerin Hugo¹,Brandelet Géraldine³,Arnoux Pascal³,Lechardeur Delphine¹^ORCID

Affiliation:

1. Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France

2. I2BC, CNRS UMR 9198, CEA Saclay, Gif-sur-Yvette, France

3. Aix Marseille Université, CEA, CNRS, BIAM, Saint Paul-Lez-Durance, France

Abstract

Enterococcus faecalis , a normal and harmless colonizer of the human intestinal flora can cause severe infectious diseases in immunocompromised patients, particularly those that have been heavily treated with antibiotics. Therefore, it is important to understand the factors that promote its resistance and its virulence. E. faecalis , which cannot synthesize heme, an essential but toxic metabolite, needs to scavenge this molecule from the host to respire and fight stress generated by oxidants.

Funder

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03392-20

Reference45 articles.

1. The rise of the Enterococcus: beyond vancomycin resistance

2. Agudelo Higuita NI, Huycke MM. 2014. Enterococcal disease, epidemiology, and implications for treatment. In Gilmore MS, Clewell DB, Ike Y, Shankar N (ed), Enterococci: from commensals to leading causes of drug resistant infection. Massachusetts Eye and Ear Infirmary, Boston, MA.

3. Longitudinal (2001–14) analysis of enterococci and VRE causing invasive infections in European and US hospitals, including a contemporary (2010–13) analysis of oritavancin in vitro potency

4. Raising the Alarmone: Within-Host Evolution of Antibiotic-Tolerant Enterococcus faecium

5. Environmental Heme Utilization by Heme-Auxotrophic Bacteria

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Heme homeostasis and its regulation by hemoproteins in bacteria;mLife;2024-07-11

2. Decrease of ESKAPE virulence with a cationic heme-mimetic gallium porphyrin photosensitizer: The Trojan horse strategy that could help address antimicrobial resistance;Journal of Photochemistry and Photobiology B: Biology;2024-07

3. HssS activation by membrane heme defines a paradigm for two-component system signaling in Staphylococcus aureus;mBio;2024-06-12

4. Biosynthesis, acquisition, regulation, and upcycling of heme: recent advances;Critical Reviews in Biotechnology;2024-01-16

5. Liberation of host heme by Clostridioides difficile- mediated damage enhances Enterococcus faecalis fitness during infection;mBio;2024-01-16