Avian Influenza A Virus Polymerase Can Utilize Human ANP32 Proteins To Support cRNA but Not vRNA Synthesis-Reference-Cited by-同舟云学术

Avian Influenza A Virus Polymerase Can Utilize Human ANP32 Proteins To Support cRNA but Not vRNA Synthesis

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Swann Olivia C.¹^ORCID,Rasmussen Amalie B.¹^ORCID,Peacock Thomas P.¹^ORCID,Sheppard Carol M.¹^ORCID,Barclay Wendy S.¹^ORCID

Affiliation:

1. Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, United Kingdom

Abstract

To infect humans and cause a pandemic, avian influenza must first adapt to use human versions of the proteins the virus hijacks for replication, instead of the avian orthologues found in bird cells. One critical host protein is ANP32.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03399-22

Reference37 articles.

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1. Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase;Nature Communications;2024-08-19

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4. 5′ copyback defective viral genomes are major component in clinical and non-clinical influenza samples;Virus Research;2024-01

5. An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization;Nature Communications;2023-10-10