The ER Protein Translocation Channel Subunit Sbh1 Controls Virulence of Cryptococcus neoformans-Reference-Cited by-同舟云学术

The ER Protein Translocation Channel Subunit Sbh1 Controls Virulence of Cryptococcus neoformans

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Santiago-Tirado Felipe H.¹^ORCID,Hurtaux Thomas¹,Geddes-McAlister Jennifer²^ORCID,Nguyen Duy³,Helms Volkhard³,Doering Tamara L.¹^ORCID,Römisch Karin⁴

Affiliation:

1. Department of Molecular Microbiology, Washington University Medical School, St. Louis, Missouri, USA

2. Department of Molecular and Cellular Biology, University of Guelph, Ontario, Canada

3. Center for Bioinformatics, Faculty of Natural Sciences and Technology, Saarland University, Saarbruecken, Germany

4. Department of Biology, Faculty of Natural Sciences and Technology, Saarland University, Saarbruecken, Germany

Abstract

Cryptococcus neoformans is a yeast that causes almost 200,000 deaths worldwide each year, mainly of immunocompromised individuals. The surface structures of this pathogen, a protective cell wall surrounded by a polysaccharide capsule, are made and maintained by proteins that are synthesized inside the cell and travel outwards through the secretory pathway.

Funder

Canada Foundation for Innovation

Canadian Institutes for Health Research

Burroughs Wellcome Fund

Deutsche Forschungsgemeinschaft

HHS | NIH | National Institute of Allergy and Infectious Diseases

Universität des Saarlandes

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03384-22

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