IS <i>26</i> Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics-Reference-Cited by-同舟云学术

IS 26 Veers Genomic Plasticity and Genetic Rearrangement toward Carbapenem Hyperresistance under Sublethal Antibiotics

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wei Da-Wei¹²^ORCID,Wong Nai-Kei³,Song Yuqin¹,Zhang Gang¹,Wang Chao¹,Li Juan⁴,Feng Jie¹^ORCID

Affiliation:

1. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

2. College of Life Science, University of Chinese Academy of Sciences, Beijing, China

3. Clinical Pharmacology Section, Department of Pharmacology, Shantou University Medical College, Shantou, China

4. State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Changping, Beijing, China

Abstract

Klebsiella pneumoniae carbapenemases (KPCs) are powerful β -lactamases that enable Gram-negative pathogens to destroy clinically important carbapenems in antibiotic therapies. In particular, KPC-2 is difficult to detect due to a lack of instrument sensitivity in regular laboratory screens, which leads to misdiagnosis and poor treatment outcomes.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03340-21

Reference27 articles.

1. Antibiotic combinations that exploit heteroresistance to multiple drugs effectively control infection

2. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria

3. Rapid Induction of High-Level Carbapenem Resistance in Heteroresistant KPC-Producing Klebsiella pneumoniae