cotH Genes Are Necessary for Normal Spore Formation and Virulence in Mucor lusitanicus

Author:

Szebenyi Csilla12,Gu Yiyou3,Gebremariam Teclegiorgis3,Kocsubé Sándor12,Kiss-Vetráb Sándor12,Jáger Olivér12,Patai Roland4,Spisák Krisztina45,Sinka Rita6,Binder Ulrike7,Homa Mónika12,Vágvölgyi Csaba12,Ibrahim Ashraf S.38ORCID,Nagy Gábor12,Papp Tamás12

Affiliation:

1. Department of Microbiology, University of Szeged, Szeged, Hungary

2. ELKH-SZTE Fungal Pathomechanisms Research Group, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary

3. Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA

4. Institute of Biophysics, Biological Research Centre, Szeged, Hungary

5. Doctoral School of Theoretical Medicine, University of Szeged, Szeged, Hungary

6. Department of Genetics, University of Szeged, Szeged, Hungary

7. Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria

8. David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Abstract

Current treatment options for mucormycosis are inadequate, resulting in high mortality rates, especially among immunosuppressed patients. The development of novel therapies for mucormycosis has been hampered by lack of understanding of the pathogenetic mechanisms.

Funder

Hungarian Academy of Sciences

ELKH

National Research, Development and Innovation Fund

Ministry of Human Capacities

HHS | NIH | National Institute of Allergy and Infectious Diseases

NKFI | Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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