Small-Molecule Mn Antioxidants in Caenorhabditis elegans and Deinococcus radiodurans Supplant MnSOD Enzymes during Aging and Irradiation

Author:

Gaidamakova Elena K.12,Sharma Ajay34,Matrosova Vera Y.12,Grichenko Olga12,Volpe Robert P.12,Tkavc Rok125,Conze Isabel H.167,Klimenkova Polina12,Balygina Irina18,Horne William H.19,Gostinčar Cene10ORCID,Chen Xiao11,Makarova Kira S.12,Shuryak Igor13,Srinivasan Chandra14,Jackson-Thompson Belinda12,Hoffman Brian M.34,Daly Michael J.1ORCID

Affiliation:

1. Department of Pathology, School of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA

2. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA

3. Department of Chemistry, Northwestern University, Evanston, Illinois, USA

4. Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA

5. Department of Microbiology and Immunology, School of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA

6. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

7. Institute for Genetics, University of Cologne, Cologne, Germany

8. Novosibirsk State University, Novosibirsk, Russia

9. Department of Chemistry and Life Science, United States Military Academy, West Point, New York, USA

10. Department of Biology, University of Ljubljana, Biotechnical Faculty, Ljubljana, Slovenia

11. IGM Biosciences, Mountain View, California, USA

12. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA

13. Center for Radiological Research, Columbia University Irving Medical Center, New York, New York, USA

14. Department of Chemistry & Biochemistry, California State University, Dominguez Hills, California, USA

Abstract

The current theory of cellular defense against oxidative damage identifies antioxidant enzymes as primary defenders against ROS, with MnSOD being the preeminent superoxide (O 2 •− ) scavenger. However, MnSOD is shown to be dispensable both for radiation resistance and longevity in model organisms, the bacterium Deinococcus radiodurans and the nematode Caenorhabditis elegans .

Funder

HHS | NIH | OSC | Common Fund

DOD | Defense Threat Reduction Agency

Slovenian Research Agency

NIH intramural research program

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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