An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation-Reference-Cited by-同舟云学术

An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation

Published:2021-07-26 Issue:16 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Mumby Mitchell J.¹,Johnson Aaron L.¹,Trothen Steven M.¹,Edgar Cassandra R.¹,Gibson Richard¹,Stathopulos Peter B.²,Arts Eric J.¹³,Dikeakos Jimmy D.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

2. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

3. Joint Clinical Research Center, Kampala, Uganda

Abstract

A contributing factor to HIV-1 persistence is evasion of the host immune response. HIV-1 uses the Nef accessory protein to evade the antiviral roles of the adaptive and intrinsic innate immune responses.

Funder

Canadian Foundation for Innovation

Gouvernement du Canada | Canadian Institutes of Health Research

Government of Ontario

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00588-21

Reference48 articles.

1. Mutations in thenefandvifgenes associated with progression to AIDS in elite controller and slow-progressor Patients