Characterization of Pyridomycin B Reveals the Formation of Functional Groups in Antimycobacterial Pyridomycin-Reference-Cited by-同舟云学术

Characterization of Pyridomycin B Reveals the Formation of Functional Groups in Antimycobacterial Pyridomycin

Published:2022-03-22 Issue:6 Volume:88 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Huang Tingting¹²^ORCID,Zhou Zihua¹²,Wei Maolong¹²,Chen Lin¹²,Xiao Zhihong¹²,Deng Zixin¹²,Lin Shuangjun¹²

Affiliation:

1. State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

2. Joint International Research Laboratory on Metabolic and Developmental Sciences, Shanghai Jiao Tong University, Shanghai, China

Abstract

Tuberculosis (TB) is one of the world’s leading causes of death by infection. Recently, pyridomycin, the antituberculous natural product from Streptomyces has garnered considerable attention for being determined as a target inhibitor of InhA enoyl reductase of Mycobacterium tuberculosis .

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.02035-21

Reference34 articles.

1. World Health Organization. 2018. 2018 Global tuberculosis report. World Health Organization, Geneva, Switzerland.

2. Tuberculosis drug discovery in the post‐post‐genomic era

3. Recent developments in natural product-based drug discovery for tuberculosis

4. Novel and revisited approaches in antituberculosis drug discovery

5. Target discovery focused approaches to overcome bottlenecks in the exploitation of antimycobacterial natural products

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