Affiliation:
1. Department of Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
Abstract
Growth of
Mycoplasma pneumoniae
was completely prevented by 0.06 μg of actinomycin D/ml, and 0.00375 μg/ml caused 90% inhibition. It thus appears that
M. pneumoniae
is more susceptible to actinomycin D than previously reported. Low concentrations (0.019 μg/ml) of the antibiotic primarily inhibited ribonucleic acid synthesis and high concentrations (20 μg/ml) inhibited both ribonucleic and deoxyribonucleic acid synthesis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference3 articles.
1. Effect of actinomycin D and glucagon on glucose uptake by spheroplasts of E. coli;Candila J. L.;Life Sci.,1970
2. On the differential cytotoxicity of actinomycin D;Sawicki S. G.;J. Cell Biol.,1971
3. Tourtellotte M. E. 1969. Protein synthesis in mycoplasmas p. 451. In L. Hayflick (ed.) Mycoplasmatales and the L-phase of bacteria. Appleton-Century-Crofts New York.
Cited by
2 articles.
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