Antiviral Effects of Aphidicolin, a New Antibiotic Produced by Cephalosporium aphidicola-Reference-Cited by-同舟云学术

Antiviral Effects of Aphidicolin, a New Antibiotic Produced by Cephalosporium aphidicola

Published:1973-09 Issue:3 Volume:4 Page:294-298
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bucknall R. A.¹,Moores H.¹,Simms R.¹,Hesp B.¹

Affiliation:

1. Imperial Chemical Industries Ltd., Pharmaceuticals Division, Alderley Park, Macclesfield, Chesire, England

Abstract

Aphidicolin is an antibiotic of novel structure produced by the mold Cephalosporium aphidicola . It is a potent inhibitor of cellular deoxyribonucleic acid synthesis, and it also strongly inhibits the growth of herpes simplex virus both in tissue culture and in the rabbit eye. Aphidicolin is active against iododeoxyuridine-resistant herpes virus, and does not itself readily induce the formation of drug-resistant strains of herpesvirus.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.4.3.294

Reference7 articles.

1. X-ray crystallographic determination of the structure of the antibiotic Aphidicolin: a tetracycline diterpenoid containing a new ring system;Brundret K. M.;J. Chem. Soc. D. Chemical Commun.,1972

2. The effects of substituted benzimidazoles on the growth of viruses and the nucleic acid metabolism of host cells;Bucknall R. A.;J. Gen. Virol.,1967

3. Clinical studies with systemic administration of antimetabolites of pyrimidine nucleosides in viral infections;Calabresi P.;Ann. N. Y. Acad. Sci.,1965

4. Incorporation of IUdR into DNA of mouse Erlich ascites cells;Prusoff W. H.;Biochim. Biophys. Acta,1960

5. Some biological aspects of herpes virus cell interactions in the presence of 5-iodo-2'-deoxyuridine;Smith K.;J. Immunol.,1963

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