Accidental Selection and Intentional Restoration of Sporulation-DeficientBacillus anthracisMutants-Reference-Cited by-同舟云学术

Accidental Selection and Intentional Restoration of Sporulation-DeficientBacillus anthracisMutants

Published:2010-09-15 Issue:18 Volume:76 Page:6318-6321
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Sastalla Inka¹,Rosovitz M. J.¹,Leppla Stephen H.¹

Affiliation:

1. Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3202

Abstract

ABSTRACTWe demonstrate the frequent accidental enrichment of spontaneous sporulation-deficient mutants ofBacillus anthracison solid medium and identify contributing factors. Mutations inspo0A, encoding the master regulator of sporulation initiation, were found in 38 of 53 mutants. Transductions using bacteriophage CP51 propagated on sporogenic bacteria allowed for the restoration of sporulation phenotypes.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00950-10

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