Chondromodulin I Is a Bone Remodeling Factor-Reference-Cited by-同舟云学术

Chondromodulin I Is a Bone Remodeling Factor

Published:2003-01-15 Issue:2 Volume:23 Page:636-644
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Nakamichi Yuko¹²,Shukunami Chisa³,Yamada Takashi¹⁴,Aihara Ken-ichi¹,Kawano Hirotaka⁴,Sato Takashi¹⁵,Nishizaki Yuriko³,Yamamoto Yoko¹,Shindo Masayo¹,Yoshimura Kimihiro¹,Nakamura Takashi¹,Takahashi Naoyuki²,Kawaguchi Hiroshi⁴,Hiraki Yuji³,Kato Shigeaki¹⁵

Affiliation:

1. The Institute of Molecular and Cellular Biosciences

2. The Institute for Oral Science, Matsumoto Dental University, Hiro-oka, Shiojiri, Nagano

3. The Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, Kyoto

4. The Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo

5. CREST, Japan Science and Technology, Kawaguchi, Saitama, Japan

Abstract

ABSTRACT Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I −/− mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I −/− mice. Thus, the present study established that ChM-I is a bone remodeling factor.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.23.2.636-644.2003

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