Assessment of fecal bacteria with bile acid 7 alpha-dehydroxylating activity for the presence of bai-like genes-Reference-Cited by-同舟云学术

Assessment of fecal bacteria with bile acid 7 alpha-dehydroxylating activity for the presence of bai-like genes

Published:1997-03 Issue:3 Volume:63 Page:1185-1188
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Doerner K C¹,Takamine F¹,LaVoie C P¹,Mallonee D H¹,Hylemon P B¹

Affiliation:

1. Department of Microbiology and Immunology, Virginia Commonwealth University-Medical College of Virginia, Richmond 23298-0678, USA.

Abstract

Eubacterium sp. strain VPI 12708 has several bile acid-inducible (bai) genes which encode enzymes in the bile acid 7 alpha-dehydroxylation (7 alpha DeOH) pathway. Twelve 7 alpha DeOH-positive intestinal bacterial strains were assayed for 7 alpha DeOH activity, and 13 strains were tested for hybridization with bai genes. Cholic acid 7 alpha DeOH activity varied greatly (> 100-fold) among these strains. Southern blot experiments showed that DNA prepared from 7 of 13 strains hybridized with at least one of the bai genes from Eubacterium sp. strain VPI 12708.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.63.3.1185-1188.1997

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