Affiliation:
1. Stella Duncan Memorial Institute and the Department of Microbiology, University of Montana, Missoula, Montana 59801
Abstract
The susceptibility of 4- to 6-week-old female white Swiss mice to intravaginal inoculation with
Herpesvirus hominis
type 2 (HVH2) and the effect of prior intravenous immunization with
Mycobacterium bovis
(BCG) and/or treatment with specific HVH2 antiserum (SAS) were investigated. Mice inoculated intravaginally developed vaginitis, posterior paralysis, encephalitis, and death. Prior immunization with BCG either had no effect or appeared in some cases to enhance the course of the disease, whereas a single 0.5-ml intravenous injection of SAS provided significant protection. However, synergistic interaction of BCG immunization and treatment with SAS produced the greatest degree of protection in mice challenged intravaginally with HVH2.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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