Affiliation:
1. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
Abstract
ABSTRACT
Infection of mice with
Mycobacterium avium
or immunization with a novel PE gene expressed by
M. avium
(MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with
Mycobacterium tuberculosis
, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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Mycobacterium tuberculosis
Antigens with Potential as Diagnostic Reagents or Subunit Vaccine Candidates by Comparative Genomics
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