The Majority of Typhoid Toxin-Positive Salmonella Serovars Encode ArtB, an Alternate Binding Subunit-Reference-Cited by-同舟云学术

The Majority of Typhoid Toxin-Positive Salmonella Serovars Encode ArtB, an Alternate Binding Subunit

Published:2021-02-24 Issue:1 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Gaballa A.¹,Cheng R. A.¹^ORCID,Harrand A. S.¹,Cohn A. R.²,Wiedmann M.¹

Affiliation:

1. Department of Food Science, Cornell University, Ithaca, New York, USA

2. Department of Microbiology, Cornell University, Ithaca, New York, USA

Abstract

While previous reports had suggested that the typhoid toxin (TT) could potentially use ArtB as an alternate binding subunit, this was thought to play a minor role in the evolution and biology of the toxin. In this study, we establish that both TT genes and artB are widespread among Salmonella enterica subsp. enterica , suggesting that TT likely plays a broader role in Salmonella virulence that extends beyond its proposed role in typhoid fever.

Funder

HHS | National Institutes of Health

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.01255-20

Reference74 articles.

1. World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010

2. Supplement 2008–2010 (no. 48) to the White–Kauffmann–Le Minor scheme