Affiliation:
1. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
Abstract
Iron is an essential micronutrient for living cells.
Candida albicans
, the predominant human fungal pathogen, thrives under diverse environments with vastly different iron levels in the mammalian host. Therefore, to tightly control iron homeostasis,
C. albicans
has evolved a set of transcriptional regulators that cooperate to either upregulate or downregulate transcription of iron uptake genes or iron utilization genes. Cap2/Hap43, a critical transcriptional regulator, contains multiple conserved protein domains. In this study, we carried out mutational analyses to identify the functional roles of the conserved protein domains in Cap2. Our results show that the bZIP, HAP4L, and the C-terminal domain are each required for Cap2 transcriptional activity. Thus, Cap2 employs multiple, disparate protein domains for regulation of iron homeostasis in
C. albicans
.
Funder
Department of Biotechnology , Ministry of Science and Technology
Department of Science and Technology, Ministry of Science and Technology
University Grants Commission
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献