Machine Learning Prediction and Experimental Validation of Antigenic Drift in H3 Influenza A Viruses in Swine-Reference-Cited by-同舟云学术

Machine Learning Prediction and Experimental Validation of Antigenic Drift in H3 Influenza A Viruses in Swine

Published:2021-04-28 Issue:2 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Zeller Michael A.¹²^ORCID,Gauger Phillip C.¹^ORCID,Arendsee Zebulun W.³^ORCID,Souza Carine K.³,Vincent Amy L.³^ORCID,Anderson Tavis K.³^ORCID

Affiliation:

1. Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa, USA

2. Bioinformatics and Computational Biology Program, Iowa State University, Ames, Iowa, USA

3. Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS, Ames, Iowa, USA

Abstract

Influenza A viruses (IAV) in swine constitute a major economic burden to an important global agricultural sector, impact food security, and are a public health threat. Despite significant improvement in surveillance for IAV in swine over the past 10 years, sequence data have not been integrated into a systematic vaccine strain selection process for predicting antigenic phenotype and identifying determinants of antigenic drift.

Funder

Iowa State University Presidential Interdisciplinary Research Initiative

Iowa State University Veterinary Diagnostic Laboratory

DOD | Defense Advanced Research Projects Agency

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Energy

USDA | Agricultural Research Service

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00920-20

Reference52 articles.

1. Dykhuis- Haden C Painter T Fangman T Holtkamp D. 2012. Assessing production parameters and economic impact of swine influenza PRRS and Mycoplasma hyopneumoniae on finishing pigs in a large production system. Abstr Am Assoc Swine Veterinarians Denver CO.

2. Polymorphism and evolution of influenza A virus genes.

3. Optimal Use of Vaccines for Control of Influenza A Virus in Swine

4. Efficacy of inactivated swine influenza virus vaccines against the 2009 A/H1N1 influenza virus in pigs

5. Efficacy of vaccination of pigs with different H1N1 swine influenza viruses using a recent challenge strain and different parameters of protection

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. MAIVeSS: streamlined selection of antigenically matched, high-yield viruses for seasonal influenza vaccine production;Nature Communications;2024-02-06

2. classLog: Logistic regression for the classification of genetic sequences;Frontiers in Virology;2023-12-04

3. InflANNet: a neural network predictor for Influenza A CTL and HTL epitopes to aid robust vaccine design;Bulletin of the National Research Centre;2023-08-22

4. InflANNet: A neural network predictor for Influenza A CTL & HTL epitopes to aid robust vaccine design;2023-07-31

5. Prediction of Antigenic Distance in Influenza A Using Attribute Network Embedding;Viruses;2023-06-29