The Passenger Domain of Bartonella bacilliformis BafA Promotes Endothelial Cell Angiogenesis via the VEGF Receptor Signaling Pathway

Author:

Tsukamoto Kentaro1ORCID,Kumadaki Kayo1,Tatematsu Kaoru1,Suzuki Natsumi1,Doi Yohei123ORCID

Affiliation:

1. Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

2. Department of Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

3. Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Abstract

Bartonella bacilliformis causes life-threatening bacteremia or dermal eruption known as Carrion’s disease in South America. During infection, B. bacilliformis promotes endothelial cell proliferation and the angiogenic process, but the underlying molecular mechanism has not been well understood.

Funder

Ohyama Health Foundation

The Ichiro Kanehara Foundation

Department of Advanced Medicine, Nagoya University Hospital

Joint Research of the Exploratory Research Center on Life and Living Systems

MEXT | Japan Society for the Promotion of Science

The Institute for Fermentation, Osaka

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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