Gut-Spleen Axis: Microbiota via Vascular and Immune Pathways Improve Busulfan-Induced Spleen Disruption-Reference-Cited by-同舟云学术

Gut-Spleen Axis: Microbiota via Vascular and Immune Pathways Improve Busulfan-Induced Spleen Disruption

Published:2023-02-21 Issue:1 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Fang Hanhan¹²,Feng Xiaohui²,Xu Tao¹,Zhong Ruqing²,Lu Dongxin¹²,Zhang Hongfu²³,Shen Wei¹,Zhao Yong²³^ORCID,Chen Liang²,Wang Junjie¹

Affiliation:

1. College of Life Sciences, Qingdao Agricultural University, Qingdao, People’s Republic of China

2. State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, People’s Republic of China

3. College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia

Abstract

Alginate oligosaccharide (AOS)-improved gut microbiota (A10-FMT) can rescue busulfan disrupted spleen vasculature. A10-FMT improved the cell proliferation rate, endothelial progenitor cell capability, and cell junction molecules to increase vasculature formation in the spleen. This reestablishment restored spleen function by improving spleen immune cells and iron metabolism. These findings are useful for the treatment of spleen vasculature-related diseases.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00581-22

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