Potent <i>In Vitro</i> and <i>Ex Vivo</i> Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A-Reference-Cited by-同舟云学术

Potent In Vitro and Ex Vivo Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A

Published:2022-10-26 Issue:5 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Edwards Jennifer L.¹²^ORCID,Balthazar Jacqueline T.³,Esposito Danillo L. A.¹,Ayala Julio C.³,Schiefer Andrea⁴⁵,Pfarr Kenneth⁴⁵^ORCID,Hoerauf Achim⁴⁵,Alt Silke⁶,Hesterkamp Thomas⁶,Grosse Miriam⁷⁸,Stadler Marc⁷⁸,Golparian Daniel⁹,Unemo Magnus⁹¹⁰,Read Timothy D.¹¹¹²^ORCID,Shafer William M.³¹²¹³^ORCID

Affiliation:

1. The Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA

2. The Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA

3. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

4. Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany

5. German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany

6. Translational Project Management Office (TPMO), German Center for Infection Research, Braunschweig, Germany

7. Department Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Germany

8. German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig, Germany

9. WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

10. Institute for Global Health, University College London, London, United Kingdom

11. Department of Medicine, Division of Infectious Disease, Emory University School of Medicine, Atlanta, Georgia, USA

12. The Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA

13. Laboratories of Bacterial Pathogenesis, Veterans Affairs Medical Center (Atlanta), Decatur, Georgia, USA

Abstract

The high global incidence of gonorrhea, the lack of a protective vaccine, and the emergence of N. gonorrhoeae strains expressing resistance to currently used antibiotics demand that new treatment options be developed. Accordingly, we investigated whether corallopyronin A, an antibiotic which is effective against other pathogens, including C. trachomatis , which together with gonococci frequently cause co-infections in humans, could exert anti-gonococcal action in vitro and ex vivo , and potential resistance emergence.

Funder

NIAID

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00362-22

Reference54 articles.

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