Four-Dimensional Characterization of the Babesia divergens Asexual Life Cycle, from the Trophozoite to the Multiparasite Stage

Author:

Conesa José Javier12,Sevilla Elena3,Terrón María Carmen4,González Luis Miguel3,Gray Jeremy5,Pérez-Berná Ana J.2,Carrascosa José L.1,Pereiro Eva2,Chichón Francisco Javier1,Luque Daniel4,Montero Estrella3

Affiliation:

1. Department of Structure of Macromolecules, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC), Madrid, Spain

2. Mistral Beamline, Experiment Division, ALBA Synchrotron (ALBA-CELLS), Barcelona, Spain

3. Parasitology Reference and Research Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain

4. Electron and Confocal Microscopy Unit, Unidades Centrales Científico-Técnicas (SG-SAFI), Instituto de Salud Carlos III, Majadahonda, Madrid, Spain

5. UCD School of Biology and Environmental Science, University College Dublin, Dublin, Ireland

Abstract

Babesiosis is a disease caused by intraerythrocytic Babesia parasites, which possess many clinical features that are similar to those of malaria. This worldwide disease is increasing in frequency and geographical range and has a significant impact on human and animal health. Babesia divergens is one of the species responsible for human and cattle babesiosis causing death unless treated promptly. When B. divergens infects its vertebrate hosts, it reproduces asexually within red blood cells. During its asexual life cycle, B. divergens builds a population of numerous intraerythrocytic (IE) parasites of difficult interpretation. This complex population is largely unexplored, and we have therefore combined three- and four-dimensional imaging techniques to elucidate the origin, architecture, and kinetics of IE parasites. Unveiling the nature of these parasites has provided a vision of the B. divergens asexual cycle in unprecedented detail and is a key step to develop control strategies against babesiosis.

Funder

Ministerio de Economía y Competitividad, Spain

Alba Synchotron

Alba Synchrotron

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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