Analysis of Serial Multidrug-Resistant Tuberculosis Strains Causing Treatment Failure and Within-Host Evolution by Whole-Genome Sequencing-Reference-Cited by-同舟云学术

Analysis of Serial Multidrug-Resistant Tuberculosis Strains Causing Treatment Failure and Within-Host Evolution by Whole-Genome Sequencing

Published:2020-12-23 Issue:6 Volume:5 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Chen Xinchang¹,He Guiqing²,Lin Siran¹,Wang Shiyong¹,Sun Feng¹,Chen Jiazhen¹,Zhang Wenhong¹³⁴⁵^ORCID

Affiliation:

1. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China

2. Department of Infectious Diseases, Wenzhou Central Hospital, Affiliated Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, China

3. State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China

4. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

5. Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

Abstract

Few studies have focused on the reasons for the low cure rate of multidrug-resistant tuberculosis in China and within-host evolution during treatment, which is of great significance for improving clinical treatment regimens. Acquired resistance events were common during the ineffective treatment, among which resistance to amikacin and high-level moxifloxacin were the most common.

Funder

National Science and Technology Major Project of China

National Natural Science Foundation of China

Zhejiang Provincial Department of Science and Technology | Basic Public Welfare Research Program of Zhejiang Province

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00884-20

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1. Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study