Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localized in the Polymerase (3D pol )-Encoding Region-Reference-Cited by-同舟云学术

Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localized in the Polymerase (3D pol )-Encoding Region

Published:2021-08-25 Issue:4 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Lasecka-Dykes Lidia¹^ORCID,Tulloch Fiona²,Simmonds Peter³^ORCID,Luke Garry A.²,Ribeca Paolo¹,Gold Sarah¹,Knowles Nick J.¹,Wright Caroline F.¹,Wadsworth Jemma¹,Azhar Mehreen¹,King Donald P.¹,Tuthill Tobias J.¹,Jackson Terry¹,Ryan Martin D.²

Affiliation:

1. The Pirbright Institute, Pirbright, Surrey, United Kingdom

2. Biomedical Sciences Research Complex (BSRC), School of Biology, University of St. Andrews, St. Andrews, United Kingdom

3. Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom

Abstract

Some RNA structures formed by the genomes of RNA viruses are critical for viral replication. Our study shows that of 46 conserved RNA structures located within the regions of the foot-and-mouth disease virus (FMDV) genome that encode the nonstructural proteins, only 3 are essential for replication of an FMDV subgenomic replicon.

Funder

Department for Environment, Food and Rural Affairs, UK Government

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00015-21

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