The Stickland Reaction Precursor <i>trans</i> -4-Hydroxy- <scp>l</scp> -Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal <i>Clostridia</i>-Reference-Cited by-同舟云学术

The Stickland Reaction Precursor trans -4-Hydroxy- l -Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

Published:2022-04-27 Issue:2 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Reed A. D.¹,Fletcher J. R.¹,Huang Y. Y.²^ORCID,Thanissery R.¹,Rivera A. J.¹,Parsons R. J.¹,Stewart A. K.³,Kountz D. J.²,Shen A.⁴^ORCID,Balskus E. P.²,Theriot C. M.¹^ORCID

Affiliation:

1. Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

2. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA

3. Molecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, North Carolina, USA

4. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA

Abstract

Proline is an essential environmental amino acid that C. difficile uses to support growth and cause significant disease. A posttranslationally modified form, hydroxyproline, is highly abundant in collagen, which is degraded by host proteases in response to C. difficile toxin activity.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00926-21

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