Glycosuria Alters Uropathogenic Escherichia coli Global Gene Expression and Virulence-Reference-Cited by-同舟云学术

Glycosuria Alters Uropathogenic Escherichia coli Global Gene Expression and Virulence

Published:2022-06-29 Issue:3 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Islam Md Jahirul¹,Bagale Kamal¹,John Preeti P.¹,Kurtz Zachary²,Kulkarni Ritwij¹^ORCID

Affiliation:

1. Department of Biology, University of Louisiana at Lafayette, Lafayette, Louisiana, USA

2. Lodo Therapeutics, New York, NY, USA

Abstract

Uropathogenic Escherichia coli (UPEC) is an important causative agent of urinary tract infections in diabetic humans. We examined the effects of in vitro exposure to glycosuria (presence of glucose in urine) on the virulence and gene expression by UPEC. Our results show that glycosuria rapidly (in 2 h) alters UPEC gene expression, induces biofilm formation, and suppresses type 1 piliation. These results offer novel insights into the pathogenesis of UPEC in the urinary tract.

Funder

University of Louisiana at Lafayette

Louisiana Board of Regents

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00004-22

Reference57 articles.

1. UROLOGIC DISEASES IN AMERICA PROJECT: TRENDS IN RESOURCE USE FOR URINARY TRACT INFECTIONS IN WOMEN