Epidemiology of Multidrug-Resistant Pseudomonas aeruginosa in the Middle East and North Africa Region

Author:

Al-Orphaly Mahmood1,Hadi Hamad Abdel2,Eltayeb Faiha Kamaleldin3,Al-Hail Hissa1,Samuel Bincy Gladson4,Sultan Ali A.4ORCID,Skariah Sini4ORCID

Affiliation:

1. Department of Medical Education, Weill Cornell Medicine - Qatar, Education City, Qatar Foundation, Doha, Qatar

2. Department of Infectious Diseases, Communicable Diseases Centre, Hamad Medical Corporation, Doha, Qatar

3. Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar

4. Department of Microbiology and Immunology, Weill Cornell Medicine - Qatar, Education City, Qatar Foundation, Doha, Qatar

Abstract

Over the last decades, there has been a dramatic global increase in multidrug-resistant (MDR) pathogens particularly among Gram-negative bacteria (GNB). Pseudomonas aeruginosa is responsible for various health care-associated infections, while MDR P. aeruginosa causes significant morbidity and mortality. Middle East and North Africa (MENA) represent an unexplored geographical region for the study of drug resistance since many of these countries are at crossroads of high volume of travel, diverse expatriate populations, as well as high antibiotic consumption despite attempts to implement antimicrobial stewardship programs.

Funder

QF | Qatar National Research Fund

Weill Cornell Medicine-Qatar

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference107 articles.

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3. The Review on Antimicrobial Resistance. 2016. Tackling drug-resistant infections globally: final report and recommendations. The Review on Antimicrobial Resistance London United Kingdom. https://amr-review.org.

4. Patient specific risk stratification for antimicrobial resistance and possible treatment strategies in gram-negative bacterial infections

5. Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study

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